Carlo Alighiero

A reporter and a blind puzzle writer investigate a series of murders connected to a pharmaceutical company conducting secret genetic experiments, finding themselves targeted by the killer.

At the behest of local revolutionaries, a mercenary enlists four old friends - all specialists in various combat styles - to help him rob a Mexican Army train carrying $500,000 in gold.

A tough, rule-bending cop pursues a maniacal, trigger-happy hunchback, a one-handed bank robber and their cronies in an effort to bring Rome's most powerful crime lord to justice.